Microstructure imaging from macro resolution MRI

Bourne R1 and Panagiotaki E2

  1. The University of Sydney.
  2. University College London.

Magnetic resonance imaging is increasingly being used to non-invasively detect diseases that have previously been characterised by biopsy and histopathology. However, the way underlying tissue microstructure affects the relatively low spatial resolution MRI signal is generally poorly understood. Further, many so-called ’advanced’ imaging techniques are in fact extremely primitive and fail to exploit the potential of modern MRI technology. This presentation looks at two new approaches that enable the estimation of specific tissue microstructure changes from sophisticated image acquisition protocols and advanced data modeling.