Liposome-based nanosensors for chemical and biological sensing

Chandrawati R

School of Chemical Engineering and Australian Centre for NanoMedicine (ACN), The University of New South Wales, Sydney, NSW 2052, Australia.

The detection of target chemical and biological molecules in a specific and sensitive manner is critical for the development of disease diagnostic devices. Membrane fusion is a key biological event that involves a highly selective recognition mechanism for molecular trafficking, facilitating communication between and within cells. The highly evolved fusion process can occur on a sub-millisecond timescale. The rapid response, specificity, and sensitivity make membrane fusion an attractive mechanism for sensing. This talk will describe our recent developments in mimicking lipid membrane fusion mechanism using liposomes for the detection of disease biomarkers. This system does not require washing, amplification or separation steps, and present a unique sensing mechanism inspired by nature.