Targeting multifactorial resistance mechanisms associated with microtubule proteins in cancer cells

Kavallaris M1,2,3

  1. Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney.
  2. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, UNSW Sydney.
  3. Australian Centre for NanoMedicine, UNSW Sydney.

Cancer is one of the major causes of morbidity and mortality in the world. A major cause of cancer treatment failure is poor access of chemotherapeutic drugs to tumour sites and resistance to therapy. Microtubules and other mitotic proteins are often deregulated in cancer and are responsible for diverse effects including drug resistance, tumour formation and metastasis. In particular, aberrant expression of specific microtubule proteins in epithelial cancers is a poor prognostic indicator and is associated with clinical resistance. Recent data on understanding the mechanisms mediating these multifactorial resistance effects and strategies to overcome resistance will be presented.