Control of receptor function through membrane embedded sequences

Call MJ1,2

  1. Structural Biology Division, The Walter and Eliza Hall Institute.
  2. Department of Medical Biology, University of Melbourne.

To sense the external environment, cells rely on receptors that span the membrane and transmit signals to the cell interior. Our understanding of how single-pass receptors transmit signals is lacking in part because we do not have full-length structures for single-pass receptors. It is becoming more apparent that single-pass receptor systems act in homo- and hetero-oligomeric formats and that the transmembrane domains of receptors play important roles in mediating signal transduction across the membrane, providing contacts around which receptor chains are organised and are targets for regulation by other cellular components. We are interrogating the function of single-pass receptors by studying interactions among transmembrane domains to develop a more comprehensive view of receptor function and regulation.