The role of mitochondrial phosphatidylethanolamine synthesis in regulating skeletal muscle lipid homeostasis

Bruce CR

Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC 3125, Australia.

Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammals. PE is synthesized via two pathways, cytidine diphosphate (CDP)-ethanolamine pathway located in the endoplasmic reticulum and the phosphatidylserine decarboxylase (PSD) pathway in the mitochondria. While the CDP-ethanolamine pathway is considered the major route for PE production in most mammalian tissues, our recent observations suggest the mitochondrial PSD pathway could be an important site of PE synthesis in muscle (Selathurai et al., 2015). Here, the results from studies exploring the role of the mitochondrial PE synthetic pathway in regulating lipid homeostasis in skeletal muscle will be discussed and will reveal unique insight into the significance of mitochondrial phospholipid synthesis in skeletal muscle. Selathurai A et al. The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity. Cell Metab 21(5):718-30, 2015.